L-Selenocystine induce HepG2 cells apoptosis through ROS-mediated signaling pathways

At present, Hepatocarcinoma is one of the main causes tumor related death all over world. However, there are still many clinical restrictions on treatment liver cancer. Recently, L-Selenocystine has been shown to be a novel for tumors, especially human glioma cells. But, mechanism against hepatocellular carcinoma remains unclear. Therefore, objective this study was investigate effects HepG2 cell proliferation and activation reactive oxygen species (ROS) mediated signaling pathway. can significantly inhibit by activating caspase-3 cleaving PARP induce apoptosis. Moreover, excessive production ROS influence Bax pathway which promote apoptosis key factors date suggest that signal transduction may provide certain reference significance induced